Human apolipoprotein A-I--C-III gene complex is located on chromosome 11.
نویسندگان
چکیده
The genes for two of the apolipoproteins, apo A-I and apo C-III, previously shown to be within 3kb in the genome, were localized to human chromosome 11 by Southern blot analysis of DNA from human-rodent somatic cell hybrids. These two genes were shown to exhibit polymorphisms associated with dyslipoproteinemia and premature atherosclerosis, and it will now be possible to examine the relationship of these genes to the many others that have been assigned to this chromosome.
منابع مشابه
Localization of the structural gene for human apolipoprotein A-I on the long arm of human chromosome 11.
Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot analysis of 13 hybrids localized the gene to human chromosome 11. Confirmation...
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عنوان ژورنال:
- Arteriosclerosis
دوره 4 2 شماره
صفحات -
تاریخ انتشار 1984